We all want to feel and look young. You may be a person who eats well, exercises, takes supplements and has a generally healthy lifestyle. But we all know that is still not enough. We see healthiest people continue to age and deteriorate.
Scientific research has discovered that a primary cause of aging is shortening of the telomeres - the protective end-caps of DNA at both ends of every chromosome. You can fight telomere shortening with diet and exercise, but only up to a point. But now you can fight it with telomerase activator.
All normal human somatic cells have a finite number of times that they can divide and when this limit is reached cells are described as cellular senescent. Telomere shortening has been attributed as a main mechanism for cellular aging and for the lack of cellular functions associated with aging. Unlike what is seen in most somatic cells, in activated T cells telomerase activity is upregulated, resulting in increased telomere length. However, this brief period of telomerase induction only delays cellular senescence. Naturally, there is a great deal of interest in finding inducers of telomerase that may help delay the onset of cellular aging. There are various nutraceuticals that claim to both increase the health of individuals and delay the onset of cellular aging.
Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression.
The regulated expression of adhesion molecules on the surface of endothelial cells is a key process in the pathogenesis of inflammation. The saponin astragaloside IV (AS-IV), a 3-O-beta-D-xylopyranosyl-6-O-beta-D-glucopyranosyl cycloastragenol purified from the Chinese medical herb Astragalus membranaceus (Fisch) Bge. has been shown to have anti-inflammatory effects in vivo. In this study we have investigated the effect of AS-IV on cytokine-and LPS-stimulated expression of adhesion molecules in and leukocyte adhesion to endothelial cells.